GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs13174348 | 1 | rs6880889 | chr5:115167896 | CDO1 | chr5:115140432-115152405:- | -0.37 | -7.27 | 1.52E-12 | IgG glycosylation |
| THCA | cis | rs10461617 | 1 | rs6885541 | chr5:56110857 | C5orf35 | chr5:56205103-56213010:+ | 1 | 22.45 | 9.16E-77 | Type 2 diabetes |
| THCA | cis | rs3853750 | 1 | rs6885792 | chr5:110165413 | TMEM232 | chr5:109624934-110062381:- | 0.21 | 4.17 | 3.66E-5 | Asthma and hay fever |
| THCA | cis | rs10037055 | 1 | rs6886255 | chr5:176718361 | MXD3 | chr5:176732501-176739292:- | -0.16 | -4.99 | 8.64E-7 | Migraine without aura |
| THCA | cis | rs6878284 | 1 | rs6886744 | chr5:101693031 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.62 | 3.21E-8 | Schizophrenia |
| THCA | cis | rs6887276 | 1 | rs6887276 | chr5:127378294 | SLC12A2 | chr5:127419483-127525379:+ | 0.12 | 3.42 | 0.000669 | Height |
| THCA | cis | rs607541 | 1 | rs688967 | chr15:45936127 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.94 | 1.08E-6 | Obesity-related traits |
| THCA | cis | rs1062177 | 1 | rs6890099 | chr5:151151962 | SPARC | chr5:151041019-151066517:- | 0.13 | 3.42 | 0.000692 | Preschool internalizing problems |
| THCA | cis | rs6890695 | 1 | rs6890695 | chr5:130888424 | P4HA2 | chr5:131528306-131563556:- | 0.22 | 4.2 | 3.25E-5 | Alzheimer's disease in APOE e4- carriers |
| THCA | cis | rs6878284 | 1 | rs6892350 | chr5:101777664 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.54 | 5.1E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs6895795 | chr5:101780797 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.54 | 5.1E-8 | Schizophrenia |
| THCA | cis | rs1010254 | 1 | rs6896780 | chr5:151735124 | NMUR2 | chr5:151771102-151784840:- | -0.51 | -9.43 | 1.73E-19 | Optic nerve measurement (cup area) |
| THCA | cis | rs690037 | 1 | rs690037 | chr3:16395668 | OXNAD1 | chr3:16306714-16378866:+ | 0.21 | 4.29 | 2.13E-5 | Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area) |
| THCA | cis | rs7744392 | 1 | rs6900530 | chr6:35280971 | C6orf106 | chr6:34555066-34664625:- | -0.35 | -3.44 | 0.000623 | Cataracts in type 2 diabetes |
| THCA | cis | rs9322817 | 1 | rs6900902 | chr6:105235757 | HACE1 | chr6:105175968-105307794:- | -0.16 | -4.02 | 6.67E-5 | Thyroid stimulating hormone |